Live Clinical and Health Research

Research studies currently recruiting

We’re keen to grow and develop Clinical and Health Research into all health areas within HWHCT. Please see below and click through for research studies that are currently recruiting participants and how you can get involved. For further information please email us.

PAMORAMIC: NEW Urgent Public Health clinical trial investigating antiviral treatments for people with COVID-19 that can be taken at home. For further information please click on the COVID-19 link below (December 2021)

Our performance in delivering research

The Government aims to increase the number of patients who have the opportunity to participate in good quality research.

To support this, the Department of Health assesses the performance of NHS providers in setting up and engaging patients in clinical trials. The Trust is required to publish its performance four times a year.

The Trust is measured on two indicators; one is the time it has taken the Trust to start a clinical trial, and the second is its delivery of commercial clinical research, to the agreed timescales and targets.

Please click on the link below to view our performance;


Mental Health

Alzheimer’s including dementia

National Centre for Mental Health (NCMH)

What is this study about?

We are trying to understand why some people experience problems with their mental health. The purpose of this study is to collect information and samples for genetic, biological, psychological and clinical research. This will allow us to look for genes and other factors which make some people more likely than others to become ill. We hope that our study will improve understanding of these conditions and help find better treatments in the future.

Who can take part?

- If you or one of your relatives have experienced a mental illness

- If neither you nor your relatives have experienced a mental illness

By comparing information from people who have experienced a mental illness with information from people who have not experienced such problems, we hope to learn more about the factors that may make some people more susceptible to these illnesses.

What is involved?

- A meeting with a member of the research team to complete a 30-60 minute assessment including patient consent

- A blood sample or if taking blood is not possible a saliva sample

- Look at your medical records to gain further details about the kinds of symptoms and treatments you have had. With permission to look at your records in the future to see if there has been any change in your health.

- May ask you if any other members of your family would like to take part as this enables us to acquire a wide base of family genetic information. However, we would only contact your relatives with your full agreement.

Alzheimer’s including Dementia

Coming soon: RE-AIM study of the PRIDE (promoting independence in dementia) self-management app

What is this study about?

Whether the PRIDE self-management web-app is feasible for people with early stage dementia and if it helps to improve quality of life and independence. The study will focus on the RE-A of the RE-AIM framework in order to explore how the PRIDE-app can support the self-management of people with early stage dementia.

Who can take part?

  • Aged 18 or over; there is no upper age limit.
  • Self-report a medically confirmed diagnosis of dementia
  • Able to engage with and participate in the intervention in the judgement of the recruiting researcher. 
  • Able to provide informed consent in the judgement of the recruiting researcher.
  • Able to read and communicate verbally in English.
  • Access to suitable technology to use the PRIDE-app and have a telephone number

What is involved?

The PRIDE-app intervention, developed from the original paper manual-based PRIDE intervention, is an online social intervention encompassing social, physical, and cognitive dimensions to promote independence for people in the early stages of dementia. It comprises an online manual which is worked through with the support of a trained facilitator across three sessions. The first session will take 60-90 minutes to complete. The second and the third sessions will be 30-60 minutes depending on each participant. All sessions will be delivered within a 2 month window.

To find out more please contact us

- Please keep the following underneath the above study:

Please go to the Join Dementia Research webpage to find out more about their service which allows people to register their interest in participating in dementia research and be matched to suitable studies.

Alzheimer’s Research UK is the UK’s leading Dementia research charity. If you have questions about dementia and dementia research please access the Dementia Research Infoline 0300 111 5111 or  To find out more and how to get involved please visit:

Anxiety & Depression

GLAD (Genetic Links to Anxiety and Depression) study logoGLAD: Genetic Links to Anxiety and Depression

What is this study about?

Depression and anxiety are the most common mental health disorders worldwide. In the UK, 1 in 3 people will experience symptoms during their lifetime. The GLAD Study aims to better understand depression and anxiety in order to find effective treatments and improve the lives of people experiencing these disorders.

The study explores how our genes and the environment influence the development of anxiety and depression in order to improve future treatment. Involvement in GLAD also involves joining the NIHR Mental Health BioResource, a central library of information about people’s health made up of genetic and clinical data.

Who can take part?

Anyone over the age of 16 who has experienced symptoms of anxiety or depression in their lifetime. There is no age limit, and participants can be NHS patients, parents/relatives/carers of patients and self-referred volunteers.

What is involved?

There are 4 simple steps to signing up to the GLAD Study:

  1. Register on the website and read the information sheet
  2. Provide consent
  3. Complete a 30 minute questionnaire to see if you are eligible
  4. Send a saliva DNA sample through the post

Once you have signed up to the GLAD Study, you will be able to see information on the website about a number of optional questionnaires or other research studies that are being carried out. You will be able to choose to take part in these studies should you wish to.

You can stop taking part in the GLAD Study at any time.

How to get involved?

To access the study go online here to learn more and to sign up. Remember to say you heard about the survey through Herefordshire and Worcestershire Health and Care NHS Trust.

BiPolar and Related Mood Disorders

Bipolar Disorder Research Network Logo Bipolar Disorder Research Network (BDRN)

What is this study about?

The BDRN team are conducting research into the causes of bipolar disorder and related mood disorders. The main aim is to identify susceptibility genes for bipolar and other related mood disorders. The study is hoping to improve the understanding of the causes of mood disorders and help find better treatments for the future.

Who can take part?

Participants will be eligible if they are aged 18+, have had a diagnosis of bipolar disorder (or a related mood disorder) and have experienced one or more episodes of mania or hypermania at any time in the past.

What is involved?

Taking part involves an interview (either in person or over the phone), completing a set of questionnaires and providing a blood sample.

Learning Difficulties

Coming soon:

BEAMS-ID (Behavioural Interventions to Treat Anxiety in Adults with Autism and Moderate to Severe Intellectual Disabilities) study logo: Behavioural Interventions to Treat Anxiety in Adults with Autism and Moderate to Sever Intellectual Disabilities

What is this study about?

To adapt an existing therapy for anxiety disorders that was developed for autistic adults without intellectual disabilities.

Who can take part?

Adults with severe intellectual disabilities

What is involved?

- Our Intervention Adaptation Group (IAG) will be comprised of 6 to 8 key stakeholders who will be representatives from our PPI partners, carers and family members, people with autism and/or intellectual disabilities, and clinicians, along with members of the research team.

- An online survey of existing community-based services within the UK to characterise Treatment as Usual (TAU)

- Single-arm non-randomised feasibility study of behavioural intervention plus TAU for the treatment of anxiety disorders amongst people with autism who have moderate to severe intellectual disabilities, and the use of qualitative and quantitative research methods to help address key components of feasibility. Recruitment will be open to participants with autism and moderate to severe intellectual disabilities who have anxiety disorders within England.


 Newly opened

NCMH (National Centre for Mental Health) logoMaternal Wellbeing, Mental Health, and Life Experience

What is this study about?

To explore the factors that may have an effect in pregnancy and in the first year after childbirth i.e. exposure to certain life events and the effects of COVID-19 on the perinatal period.

Who can take part?

ALL women aged 18 or over who are currently within the perinatal period (currently pregnant or up to 1-year postpartum)

What is involved?

- Basic assessment online

- 2 short follow up questionnaires – date for when these are completed is dependent on when the lady was recruited either when pregnant or postnatally

To find out more please contact us

Psychosis including Schizophrenia

PREFER (Patient preferences for voice-hearing therapies) study logo PREFER: Patient preferences for voice-hearing therapies

What is this study about?

To explore patient preferences for psychological therapies for the experience of hearing distressing voices.

Who can take part?

- Aged 16 and over

- Have heard voices for at least six months, irrespective of diagnosis

What is involved?

- Face to face interviews

- Online questionnaire

To find out more please contact us

To keep up to date with this study catch up on news in the most recent study newsletter: Eleventh PREFER Newsletter.pdf [pdf] 1MB


Coming soon – opening 2022

ADEPP (Antidepressant for the prevention of DEPression following first episode Psychosis) study logo ADEPP: Antidepressant for the prevention of DEPression following first episode Psychosis trial

What is this study about?

The aim of the ADEPP trial is to establish the effectiveness and cost effectiveness of an antidepressant medication (sertraline) for the prevention of a depressive episode following first episode psychosis (FEP). The study aims to recruit up to 508 participants over a period of 32 months from Early Intervention in Psychosis Services in the NHS Trusts across the UK.

Who can take part?

Patients aged between 18-35 years of age, diagnosed with FEP and within 3 months of initial treatment for FEP.

What is involved?

This is a multi-centre randomised, double-blind, placebo controlled trial with an internal pilot study.

To find out more please contact us


NEW Urgent Public Health clinical trial (Dec 2021):


What is this study about?

PAMORAMIC is a new Urgent Public Health clinical trial which aims to find antiviral treatments which can be taken at home to improve symptoms and reduce hospital admissions for people with current COVID-19 symptoms.
Who can take part?

  • People aged 50 or over or 18-49 with an underlying health condition
  • Have received a positive PCR test result in the last 5 days

What is involved?

  • A few daily questions to answer via the PANORAMIC website for 28 days
  • Contact by the study team 3 and 6 months after you started the trial to see if you have any long covid symptons
  • If randomised to receive the anitviral drug, taking this drug 
  • You can sign-up for the PANORAMIC trial today here:

ISARIC (International Severe Acute Respiratory and Emerging Infection Consortium) Clinical Characterisation Protocol (CCP) for Severe Emerging Infection - study currently paused here at HWHCT

What is this study about?

This is a study recruiting hospitalised cases of confirmed 2019 novel coronavirus infection. Standardised clinical data is being collected to improve patient care and inform the public health response.

Who can take part?

Anyone over the age of 18 who has been hospitalised with Covid 19.

What is involved?

Collecting standard clinical date for a period of time to analyse the recovery from COVID 19.